Originally, the Sinister Six were banded together by Doctor Octopus. After suffering three defeats in a row from Spider-Man, Dr. Octavius understood the need to band with other criminals. Thus, he contacted all known Spider-Man rogues. With the knowledge their group would be only for a short duration.

Only five responded. Together, Dr. Octopus, Electro, Vulture, Mysterio, Kraven the Hunter and Sandman would become the Sinister Six. Also, the group has been known as the Savage Six, the Sinister Seven and the Sinister Twelve. Let’s list 10 horrible things the villain team has done in comics and television to ruin Spider-Man’s life.

First, when they formed Doctor Octopus planned to use people important to Spider-Man as bait. Though unaware, they kidnapped Aunt May who was a bystander. In addition, they realized Betty Brant was important. So they kidnapped her. Second, the Sinister Six set up a gauntlet.

Indeed, Spider-Man had to fight each member individually in order to save the loved ones. But this was a bad time since Spider-Man had lost his powers at the time. In fact, it turned out to be a psychological block over Uncle Ben’s death. Which he overcame in life or death situations.

In Spectacular Spider-Man, the Sinister Six form for the first time in Season 1: Episode 11. After Electro breaks them out of prison, the Six attack Spider-Man’s family. No match against Doc Ock, Vulture, Shocker, Electro, Sandman and Rhino, Spider-Man retreats.

At night, Spider-Man actually wishes that his enemies end up behind bars. Previously, Spider-Man has been using the black costume. At night, the black symbiote takes over him and goes to fight the Sinister Six. The next day, Peter finds out Spider-Man captured them but cannot remember.

After the Sinister Six were freed from prison, Doc Ock brought them together. Again, he sought revenge against Spider-Man. Apparently, Kraven committed suicide so Hobgoblin took his place.

However, Doc Ock’s real plan was to conquer the world by dealing cocaine. Fortunately, Sandman had reformed. With his help, Spider-Man defeated the Sinister Six.

To prove that the Sinister Six really were out to get their foe, they attacked when he least expected them. At Christmas, Mysterio, Kraven, Sandman, Vulture, Doc Ock and Electro attack Spider-Man. When the battle turns into Spider-Man’s favor, Kraven betrays Mysterio.

In fact, he tells Spider-Man it is a robot duplicate. Soon, Spider-Man defeats the rogues. In the end, Spider-Man saves the nearby Santa Claus and Elf. Though the identity of “Master Planner”, who is Doc Ock, remains a mystery to him.

In their newest scheme, Doc Ock and his criminals planned to steal alien weaponry. When his family was threatened, the reformed Sandman recruited Spider-Man’s help.

However, the Sinister Six went on a killing spree, murdering wantonly. And Spider-Man was injured with fractures of arm and leg. In addition, it took members of the superhero community in order to finally take them down.

Similarly to Earth-616, Spider-Man: The Animated Series created the Insidious Six. Here, they were assembled by the Kingpin in order to destroy Spider-Man. Similarly, Spider-Man was suffering from a mutation disease that caused his power loss.

When they battled Spider-Man, they quickly overpowered him. In addition, they unmasked him. Not impressed by his performance, they concluded Peter Parker could not be Spider-Man. Later, Spider-Man would defeat them after regaining his powers.

In Marvel’s Spider-Man, Doc Ock brought the Sinister Six together in order to defeat Norman Osborn. Dr. Octavius released Mister Negative, Electro, Rhino, the Vulture and Scorpion to attack Manhattan.

In the gameplay, Spider-Man went around the city defeating his rogues. In the final battle, Spider-Man defeated Doc Ock atop Oscorp Tower.

Years later, Norman Osborn, the Green Goblin, was defeated by Spider-Man. Before he headed to prison, he activated a contingency plan. Contacting Spider-Man’s rogues, he put together the Sinister Twelve. Together, Scorpion led Vulture, Sandman, Electro, Chameleon, Lizard, Hydroman, Shocker, Hammerhead, Boomerang, Tombstone.

When Scorpion captured and threatened Aunt May, Spider-Man and Black Cat were blackmailed in breaking Green Goblin out of prison. Though the two made a heroic stand, they were no match for the Sinister Twelve. With the help of Captain America, Iron Man, Daredevil, Hank Pym and the FF they defeated the supervillain team.

In his latest scheme, Kingpin gathered the Sinister Six. Their mission was to retrieve the keys of the Six American Warriors. With the keys, he planned to activate the Doomsday Device. And they were successful in defeating Spider-Man and retrieving the keys.

Though Chameleon betrayed them. Dangerously, he knocked them out with a sleeping gas and freed Kingpin from a vortex, along with Captain America. In the end, the complex collapsed and the Sinister Six disbanded.

In Marvel Contest of Champions, the Sinister Six are assembled by Grandmaster. In reality, it is a contest between Grandmaster’s champions and the Collector’s champions.

When Spider-Man and the Summoner are cornered, the Spider-People of the Battlerealm come to their help. As the Spider-People defeat the other members, Spider-Man and Summoner take down Doc Ock.